{"id":4917,"date":"2022-07-28T14:37:04","date_gmt":"2022-07-28T06:37:04","guid":{"rendered":"https:\/\/aif.amtbbs.org\/?p=4917"},"modified":"2022-07-28T14:38:11","modified_gmt":"2022-07-28T06:38:11","slug":"%e4%b8%8a%e6%b5%b7%e4%ba%a4%e5%a4%a7%e5%9b%a2%e9%98%9f%e4%bd%bf%e7%94%a8%e8%81%94%e5%90%88%e6%b7%b1%e5%ba%a6%e5%ad%a6%e4%b9%a0%e4%bc%98%e5%8c%96%e4%bb%a3%e8%b0%a2%e7%bb%84%e5%ad%a6%e7%a0%94%e7%a9%b6","status":"publish","type":"post","link":"https:\/\/aif.amtbbs.org\/index.php\/2022\/07\/28\/4917\/","title":{"rendered":"\u4e0a\u6d77\u4ea4\u5927\u56e2\u961f\u4f7f\u7528\u8054\u5408\u6df1\u5ea6\u5b66\u4e60\u4f18\u5316\u4ee3\u8c22\u7ec4\u5b66\u7814\u7a76"},"content":{"rendered":"<p>\u4ee3\u8c22\u7ec4\u5b66\u662f\u4e00\u4e2a\u4e3b\u8981\u7684\u7ec4\u5b66\u8bfe\u9898\uff0c\u5728\u4ee3\u8c22\u7279\u5f81\u548c\u751f\u7269\u6807\u5fd7\u7269\u7684\u4e34\u5e8a\u5e94\u7528\u548c\u57fa\u7840\u7814\u7a76\u4e2d\u90fd\u5360\u6709\u91cd\u8981\u5730\u4f4d\u3002\u4e0d\u5e78\u7684\u662f\uff0c\u76f8\u5173\u7814\u7a76\u53d7\u5230\u8bb8\u591a\u5916\u90e8\u56e0\u7d20\u9020\u6210\u7684\u6279\u6b21\u6548\u5e94\u7684\u6311\u6218\u3002\u5728\u8fc7\u53bb\u5341\u5e74\u4e2d\uff0c\u6df1\u5ea6\u5b66\u4e60\u6280\u672f\u5df2\u6210\u4e3a\u6570\u636e\u79d1\u5b66\u4e2d\u7684\u4e3b\u8981\u5de5\u5177\uff0c\u4eba\u4eec\u53ef\u4ee5\u4ece\u5df2\u77e5\u6279\u6b21\u8bad\u7ec3\u8bca\u65ad\u7f51\u7edc\uff0c\u7136\u540e\u5c06\u5176\u63a8\u5e7f\u5230\u65b0\u6279\u6b21\u3002\u7136\u800c\uff0c\u6279\u6b21\u6548\u5e94\u4e0d\u53ef\u907f\u514d\u5730\u963b\u788d\u4e86\u8fd9\u79cd\u52aa\u529b\uff0c\u56e0\u4e3a\u6240\u8003\u8651\u7684\u4e24\u4e2a\u6279\u6b21\u53ef\u80fd\u9ad8\u5ea6\u4e0d\u5339\u914d\u3002<\/p>\n<p>\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u548c\u4e0a\u6d77\u79d1\u6280\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u63d0\u51fa\u4e86\u4e00\u4e2a\u7aef\u5230\u7aef\u7684\u6df1\u5ea6\u5b66\u4e60\u6846\u67b6\uff0c\u7528\u4e8e\u8054\u5408\u6279\u6b21\u6548\u5e94\u53bb\u9664\uff0c\u7136\u540e\u5bf9\u4ee3\u8c22\u7ec4\u5b66\u6570\u636e\u8fdb\u884c\u5206\u7c7b\u3002\u7814\u7a76\u4eba\u5458\u9996\u5148\u5728\u516c\u5171 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classification toward MALDI MS based metabolomics\u300d\u4e3a\u9898\uff0c\u4e8e 2022 \u5e74 7 \u6708 10 \u65e5\u53d1\u5e03\u5728\u300aBMC Bioinformatics\u300b\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4923\" src=\"https:\/\/aiforumimage.oss-cn-shanghai.aliyuncs.com\/wp-content\/uploads\/2022\/07\/ety1-300x90-1-1.png\" width=\"300\" height=\"90\" alt=\"\" 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src=\"https:\/\/aiforumimage.oss-cn-shanghai.aliyuncs.com\/wp-content\/uploads\/2022\/07\/ety2-300x300-1-1.png\" width=\"300\" height=\"300\" alt=\"\" srcset=\"https:\/\/aiforumimage.oss-cn-shanghai.aliyuncs.com\/wp-content\/uploads\/2022\/07\/ety2-300x300-1-1.png 300w, https:\/\/aiforumimage.oss-cn-shanghai.aliyuncs.com\/wp-content\/uploads\/2022\/07\/ety2-300x300-1-1-150x150.png 150w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>\u56fe\u793a\uff1a\u60a3\u8005\u7684\u516c\u5171 CyTOF \u6570\u636e\u7684\u53ef\u89c6\u5316\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09<\/p>\n<p>\u540c\u65f6\uff0c\u98de\u884c\u65f6\u95f4\u6d41\u5f0f\u7ec6\u80de\u4eea\uff08CyTOF\uff09\u662f\u4e00\u79cd\u65b0\u9896\u7684\u5355\u7ec6\u80de\u5206\u6790\u6280\u672f\uff0c\u5c06\u6570\u636e\u7ef4\u5ea6\u6269\u5c55\u5230\u540c\u65f6\u6d4b\u91cf 40 + \u7ec6\u80de\u53c2\u6570\u3002\u56e0\u6b64\uff0c\u5b83\u5df2\u88ab\u5e94\u7528\u4e8e\u8ddf\u8e2a\u53cd\u6620\u5404\u79cd\u7ec6\u80de\u5c5e\u6027\u7684\u751f\u7269\u6807\u5fd7\u7269\u7684\u8868\u8fbe\u6c34\u5e73\u3002<\/p>\n<p>\u867d\u7136\u975e\u9776\u5411\u4ee3\u8c22\u7ec4\u5b66\u5177\u6709\u7f16\u7801\u590d\u6742\u751f\u7269\u6837\u54c1\u7684\u80fd\u529b\uff0c\u4f46\u901a\u5e38\u5fc5\u987b\u4f7f\u7528\u590d\u6742\u7684\u6570\u636e\u89e3\u91ca\u6280\u672f\u6765\u4fc3\u8fdb\u4e34\u5e8a\u5e94\u7528\u3002\u8bb8\u591a\u4f20\u7edf\u7814\u7a76\u5728\u4eba\u7fa4\u6c34\u5e73\u4e0a\u5efa\u7acb\u4e86\u7edf\u8ba1\u5dee\u5f02\u3002<\/p>\n<p>\u7136\u800c\uff0c\u4e3a\u4e86\u4e2a\u4f53\u5316\u8bca\u65ad\u548c\u6cbb\u7597\uff0c\u5c06\u4ed6\u4eec\u7684\u53d1\u73b0\u63a8\u5e7f\u5230\u6837\u672c\u6216\u53d7\u8bd5\u8005\u6c34\u5e73\u5e76\u4e0d\u5bb9\u6613\u3002\u9274\u4e8e\u673a\u5668\u5b66\u4e60\uff0c\u5c24\u5176\u662f\u6df1\u5ea6\u5b66\u4e60\u5728\u8fc7\u53bb\u51e0\u5e74\u7684\u5feb\u901f\u53d1\u5c55\uff0c\u6709\u4e00\u79cd\u8d8b\u52bf\u662f\u91c7\u7528\u8fd9\u4e9b\u5148\u8fdb\u7684\u5de5\u5177\u4ece\u975e\u9776\u5411\u4ee3\u8c22\u7ec4\u5b66\u6570\u636e\u4e2d\u641c\u7d22\u751f\u7269\u6807\u5fd7\u7269\uff0c\u7136\u540e\u5efa\u7acb\u9002\u7528\u4e8e\u4e2a\u4f53\u60a3\u8005\u7684\u6570\u636e\u9a71\u52a8\u7684\u75be\u75c5\u6a21\u578b\u3002<\/p>\n<p>\u5c06\u673a\u5668\u5b66\u4e60\u6a21\u578b\u63a8\u5e7f\u5230\u771f\u5b9e\u6848\u4f8b\u4ee3\u8c22\u7ec4\u5b66\u6570\u636e\u7684\u4e00\u4e2a\u4e3b\u8981\u6311\u6218\u662f\u6279\u5904\u7406\u6548\u5e94\uff0c\u8fd9\u51e0\u4e4e\u662f\u4e0d\u53ef\u907f\u514d\u7684\u3002\u786e\u5207\u5730\u8bf4\uff0c\u6279\u6b21\u6548\u5e94\u89e3\u91ca\u4e86\u5728\u5b9e\u9a8c\u6761\u4ef6\u4e0b\u8868\u73b0\u4e0d\u540c\u4f46\u4e0e\u6240\u8003\u8651\u7684\u611f\u5174\u8da3\u7684\u751f\u7269\u53d8\u91cf\u65e0\u5173\u7684\u6d4b\u91cf\u3002\u6279\u6b21\u6548\u5e94\u7684\u8d77\u6e90\u662f\u5e7f\u6cdb\u7684\uff0c\u5305\u62ec\u4e0d\u540c\u7684\u5e73\u53f0\u3001\u540c\u4e00\u6837\u672c\u7684\u4e0d\u540c\u8bd5\u5242\u3001\u4e0d\u540c\u7684\u65f6\u95f4\u70b9\u83b7\u53d6\u6570\u636e\u7b49\u3002\u56e0\u6b64\uff0c\u6709\u5fc5\u8981\u5728\u8fd9\u4e9b\u4ee3\u8c22\u7ec4\u5b66\u573a\u666f\u4e2d\u6291\u5236\u6279\u6b21\u6548\u5e94\u3002<\/p>\n<p>\u6279\u6b21\u6548\u5e94\u7684\u74f6\u9888\u5728\u8fc7\u53bb\u5f15\u8d77\u4e86\u6fc0\u70c8\u7684\u7814\u7a76\u3002\u6709\u4e24\u79cd\u6291\u5236\u6279\u6b21\u6548\u5e94\u7684\u4f20\u7edf\u65b9\u6cd5\uff0c\u5373\u4f4d\u7f6e\u5c3a\u5ea6\uff08LS\uff09\u548c\u77e9\u9635\u5206\u89e3\uff08MF\uff09\u3002\u4f8b\u5982\uff0cComBat \u662f\u4e00\u79cd\u6d41\u884c\u7684 LS \u65b9\u6cd5\u3002\u5b83\u91c7\u7528\u8d1d\u53f6\u65af\u6846\u67b6\u5bf9\u6570\u636e\u8fdb\u884c\u5efa\u6a21\uff0c\u901a\u8fc7\u72ec\u7acb\u53c2\u6570\u5316\u6bcf\u4e2a\u6279\u6b21\u548c\u6bcf\u4e2a\u7279\u5f81\u7684\u4f4d\u7f6e\u548c\u89c4\u6a21\u3002\u5176\u4ed6 LS \u65b9\u6cd5\uff0c\u5305\u62ec\u8ddd\u79bb\u52a0\u6743\u9274\u522b\uff08DWD\uff09\u3001\u5355\u5411\u65b9\u5dee\u5206\u6790\uff08ANOVA\uff09\u65b9\u6cd5\u548c Ratio_G\uff0c\u5047\u8bbe\u6bcf\u4e2a\u6279\u6b21\u7684\u6570\u636e\u5206\u5e03\u6b63\u5e38\uff0c\u5e76\u76f8\u5e94\u5730\u8c03\u6574\u4e0d\u540c\u6279\u6b21\u7684\u5206\u5e03\u3002\u7136\u800c\uff0cLS \u65b9\u6cd5\u4e2d\u7684\u5047\u8bbe\u53ef\u80fd\u88ab\u8fc7\u5ea6\u7b80\u5316\uff0c\u4ee5\u5c06\u590d\u6742\u7684\u6279\u6b21\u6548\u5e94\u89c6\u4e3a\u52a0\u6cd5\u548c\u4e58\u6cd5\u5206\u91cf\u3002<\/p>\n<p>\u4f5c\u4e3a LS \u65b9\u6cd5\u7684\u66ff\u4ee3\u65b9\u6cd5\uff0c\u4ee3\u7406\u53d8\u91cf\u5206\u6790 (SVA) \u63d0\u4f9b\u4e86\u4e00\u79cd\u6d88\u9664\u6279\u6b21\u6548\u5e94\u7684 MF \u65b9\u6cd5\u3002MF \u65b9\u6cd5\u5047\u8bbe\u7531\u6279\u6b21\u6548\u5e94\u5f15\u8d77\u7684\u6570\u636e\u53d8\u5316\u4e0e\u76ee\u6807\u6807\u7b7e\u65e0\u5173\u3002\u8fd9\u6837\uff0c\u6570\u636e\u5c31\u53ef\u4ee5\u5206\u89e3\u6210\u4e24\u90e8\u5206\uff0c\u5206\u522b\u5bf9\u5e94 batch effect\u7684\u5931\u771f\u548c\u9057\u6f0f\u7684\u90e8\u5206\u3002\u7136\u800c\uff0cMF \u65b9\u6cd5\u4e2d\u7684\u5efa\u6a21\u4f9d\u8d56\u4e8e\u5bf9\u6279\u6b21\u6548\u5e94\u548c\u6570\u636e\u6807\u7b7e\u72ec\u7acb\u6027\u7684\u5047\u8bbe\uff0c\u8fd9\u5728\u5b9e\u8df5\u4e2d\u53ef\u80fd\u5e76\u4e0d\u603b\u662f\u6709\u6548\u3002<\/p>\n<p>\u901a\u5e38\uff0c\u5728\u975e\u9776\u5411\u4ee3\u8c22\u7ec4\u5b66\u8bca\u65ad\u9886\u57df\uff0c\u9700\u8981\u6784\u5efa\u4e00\u4e2a\u5224\u522b\u6a21\u578b\uff0c\u8be5\u6a21\u578b\u53ef\u4ee5\u8bad\u7ec3\u4e00\u6279\u6e90\u6570\u636e\u5e76\u5c06\u5176\u5e94\u7528\u4e8e\u9884\u6d4b\u76ee\u6807\u6279\u6570\u636e\u7684\u6807\u7b7e\u3002Ratio_G \u65b9\u6cd5\u8c03\u6574\u6570\u636e\u4ee5\u589e\u5f3a\u6807\u7b7e\u9884\u6d4b\u3002fSVA \u65b9\u6cd5\u8fd8\u80fd\u591f\u9884\u6d4b\u672a\u89c1\u6837\u672c\u7684\u6807\u7b7e\u3002<\/p>\n<p>\u5728 fSVA \u4e2d\uff0c\u9996\u5148\u4f7f\u7528 SVA \u6765\u6821\u51c6\u8bad\u7ec3\u6570\u636e\u96c6\u4e2d\u7684\u6279\u6b21\u6548\u5e94\u3002\u7136\u540e\uff0c\u5229\u7528\u5728\u8bad\u7ec3\u6570\u636e\u96c6\u4e0a\u4f30\u8ba1\u7684\u6982\u7387\u6743\u91cd\u548c\u7cfb\u6570\u6765\u6d88\u9664\u65b0\u6d4b\u8bd5\u6837\u672c\u4e2d\u7684\u6279\u6b21\u6548\u5e94\u3002\u5728\u6821\u51c6\u6570\u636e\u96c6\u4e0a\u8bad\u7ec3\u7684\u5206\u7c7b\u5668\u6700\u7ec8\u53ef\u4ee5\u5e94\u7528\u4e8e\u9884\u6d4b\u3002\u7136\u800c\uff0c\u77e9\u9635\u5206\u89e3\u6709\u65f6\u53ef\u80fd\u4f1a\u51cf\u5c11\u5f52\u56e0\u4e8e\u6279\u6b21\u6548\u5e94\u7684\u6570\u636e\u53d8\u5316\uff0c\u4f46\u4ee3\u4ef7\u662f\u51cf\u5c11\u75be\u75c5\u7ec4\u548c\u5bf9\u7167\u4e4b\u95f4\u7684\u5dee\u5f02\uff0c\u8fd9\u53cd\u8fc7\u6765\u53c8\u4f1a\u964d\u4f4e\u540e\u7eed\u5206\u6790\u4e2d\u7684\u5206\u7c7b\u51c6\u786e\u6027\u3002<\/p>\n<p>\u8fd1\u51e0\u5341\u5e74\u6765\uff0c\u6d89\u53ca\u57fa\u56e0\u7ec4\u5b66\u3001\u8f6c\u5f55\u7ec4\u5b66\u3001\u86cb\u767d\u8d28\u7ec4\u5b66\u3001\u4ee3\u8c22\u7ec4\u5b66\u548c\u653e\u5c04\u7ec4\u5b66\u7684\u9ad8\u901a\u91cf\u7ec4\u5b66\u6570\u636e\u7684\u8ba1\u7b97\u5206\u6790\u53d8\u5f97\u5f88\u6d41\u884c\u3002\u8003\u8651\u5230\u8bb8\u591a\u6d4b\u91cf\uff08\u5bf9\u5e94\u4e8e\u7279\u5f81\u7ef4\u5ea6\uff09\u548c\u901a\u5e38\u5c11\u91cf\u7684\u6837\u672c\uff08\u6216\u6837\u672c\u91cf\uff09\uff0c\u8fd9\u663e\u7136\u662f\u5bf9\u673a\u5668\u5b66\u4e60\u7684\u6311\u6218\u3002<\/p>\n<p>\u53e6\u4e00\u65b9\u9762\uff0c\u6700\u8fd1\u6df1\u5ea6\u5b66\u4e60\u7684\u98de\u8dc3\u63d0\u4f9b\u4e86\u4e00\u79cd\u524d\u6240\u672a\u6709\u7684\u5de5\u5177\u6765\u514b\u670d\u8fd9\u4e9b\u969c\u788d\u3002\u4e0d\u540c\u7c7b\u578b\u7684\u6df1\u5ea6\u5b66\u4e60\u67b6\u6784\uff0c\u5982\u5377\u79ef\u795e\u7ecf\u7f51\u7edc\uff08CNN\uff09\u3001\u9012\u5f52\u795e\u7ecf\u7f51\u7edc\uff08RNN\uff09\u3001\u957f\/\u77ed\u671f\u8bb0\u5fc6\uff08LSTM\uff09\u3001\u81ea\u52a8\u7f16\u7801\u5668\uff08AE\uff09\u548c\u751f\u6210\u5bf9\u6297\u7f51\u7edc\uff08GAN\uff09\uff0c\u5df2\u5e94\u7528\u4e8e\u5404\u79cd\u7ec4\u5b66\u7814\u7a76\u3002<\/p>\n<p>\u5b83\u5728\u4e73\u817a\u764c\u5206\u7c7b\u3001\u81ea\u52a8\u9752\u5149\u773c\u68c0\u6d4b\u3001\u4eba\u7c7b\u6b65\u6001\u8bc6\u522b\u548c\u667a\u80fd\u878d\u5408\u8f85\u52a9\u76ae\u80a4\u75c5\u53d8\u5b9a\u4f4d\u548c\u5206\u7c7b\u65b9\u9762\u4f18\u4e8e\u8bb8\u591a\u4f20\u7edf\u7684\u673a\u5668\u5b66\u4e60\u6280\u672f\u3002\u6240\u6709\u8fd9\u4e9b\u5206\u6790\u90fd\u53ef\u4ee5\u6f5c\u5728\u5730\u5e2e\u52a9\u533b\u751f\u63d0\u4f9b\u7cbe\u786e\u7684\u8bca\u65ad\u548c\u4e2a\u6027\u5316\u7684\u6cbb\u7597\u3002<\/p>\n<p>\u968f\u7740\u6df1\u5ea6\u5b66\u4e60\u7684\u666e\u53ca\uff0cShaham \u56e2\u961f\u4f7f\u7528 ResNet \u6765\u53bb\u9664\u6279\u5904\u7406\u6548\u5e94\u3002\u867d\u7136\u6df1\u5ea6\u5b66\u4e60\u5177\u6709\u903c\u8fd1\u9ad8\u5ea6\u975e\u7ebf\u6027\u6620\u5c04\u7684\u5f3a\u5927\u80fd\u529b\uff0c\u4f46 Shaham \u56e2\u961f\u7684\u89e3\u51b3\u65b9\u6848\u672c\u8d28\u4e0a\u662f\u65e0\u76d1\u7763\u7684\uff08\u5373\uff0c\u4e0d\u77e5\u9053\u6837\u672c\u7684\u75be\u75c5\u6807\u7b7e\uff09\u3002<\/p>\n<p>\u53e6\u4e00\u65b9\u9762\uff0c\u57fa\u4e8e GAN \u7684 NormAE \u5728\u975e\u7ebf\u6027 AE \u4ee5\u6d88\u9664\u6279\u6b21\u6548\u5e94\u548c\u5224\u522b\u5668\u4e4b\u95f4\u6784\u5efa\u5bf9\u6297\u6027\u8bad\u7ec3\u8fc7\u7a0b\u4ee5\u5bf9\u6279\u6b21\u6807\u7b7e\u8fdb\u884c\u5206\u7c7b\u3002\u5b66\u4e60\u7f51\u7edc\u7684\u8fa8\u522b\u529b\u5bf9\u4e8e\u4ee3\u8c22\u751f\u7269\u6807\u5fd7\u7269\u7684\u8bca\u65ad\u548c\u8bc6\u522b\u81f3\u5173\u91cd\u8981\u3002\u4e0d\u5e78\u7684\u662f\uff0c\u4ec5\u901a\u8fc7\u51cf\u5c11\u4e0d\u540c\u6279\u6b21\u4e4b\u95f4\u7684\u4e0d\u5339\u914d\uff0c\u8bca\u65ad\u6548\u679c\u4e0d\u4e00\u5b9a\u4f1a\u63d0\u9ad8\u3002<\/p>\n<p>\u53ea\u6709\u6b63\u786e\u5904\u7406\u6837\u672c\u6570\u636e\u4e4b\u95f4\u7684\u6279\u6b21\u6548\u5e94\uff0c\u540e\u7eed\u57fa\u4e8e\u5b66\u4e60\u7684\u5206\u7c7b\u548c\u8bca\u65ad\u624d\u80fd\u53d7\u76ca\u3002\u4e3a\u4e86\u89e3\u51b3\u4e0a\u8ff0\u95ee\u9898\uff0c\u4e0a\u6d77\u4ea4\u5927\u7684\u7814\u7a76\u4eba\u5458\u9488\u5bf9\u57fa\u4e8e MALDI MS \u7684\u4ee3\u8c22\u7ec4\u5b66\u5f15\u5165\u4e86\u4e00\u4e2a\u8054\u5408\u6df1\u5ea6\u5b66\u4e60\u6846\u67b6\uff0c\u9996\u5148\u6821\u51c6\u6279\u6b21\u6548\u5e94\uff0c\u7136\u540e\u8fdb\u884c\u6837\u672c\u5206\u7c7b\uff08\u4f8b\u5982\uff0c\u5f97\u51fa\u75be\u75c5\u8bca\u65ad\uff09\u3002<\/p>\n<p>\u8be5\u6846\u67b6\u7531\u4e09\u4e2a\u76f8\u4e92\u5bc6\u5207\u4ea4\u4e92\u7684\u4e3b\u8981\u7f51\u7edc\u7ec4\u6210\uff1a\uff081\uff09\u7ed9\u5b9a\u5355\u4e2a\u8f93\u5165\u6279\u6b21\u7684\u4ee3\u8c22\u7ec4\u5b66\u6570\u636e\uff0c\u5c06\u5b83\u4eec\u901a\u8fc7\u6821\u51c6\u5668\uff0c\u4f7f\u5b83\u4eec\u5728\u6f5c\u5728\u7279\u5f81\u7a7a\u95f4\u4e2d\u5bf9\u9f50\uff1b(2) \u4e00\u4e2a\u540e\u7eed\u7684\u5224\u522b\u5668\u4ece\u6f5c\u5728\u7a7a\u95f4\u4e2d\u63a8\u5bfc\u51fa\u6765\uff0c\u5728\u8bad\u7ec3\u4e2d\u53d7\u67d0\u4e2abatch\u7684\u5df2\u77e5\u6807\u7b7e\u76d1\u7763\uff0c\u5b8c\u6210\u5bf9\u53e6\u4e00\u4e2a\u6d4b\u8bd5batch\u7684\u5206\u7c7b\uff1b(3) \u91cd\u6784\u5668\u4e5f\u6e90\u81ea\u6f5c\u5728\u7279\u5f81\u7a7a\u95f4\u5e76\u6062\u590d\u6240\u6709\u8f93\u5165\u6279\u6b21\uff0c\u4ee5\u786e\u4fdd\u8f93\u5165\u6279\u6b21\u5728\u6574\u4e2a\u7f51\u7edc\u4e2d\u5f97\u5230\u5f88\u597d\u7684\u5b66\u4e60\u3002<\/p>\n<p>\u5b9e\u9a8c\u8bc1\u660e\uff0c\u8be5\u65b9\u6cd5\u53ef\u4ee5\u6709\u6548\u5730\u6d88\u9664\u6279\u6b21\u6548\u5e94\uff0c\u5e76\u4e14\u5728\u5206\u7c7b\u51c6\u786e\u6027\u65b9\u9762\u4f18\u4e8e\u6240\u6709\u6bd4\u8f83\u65b9\u6cd5\u3002\u8fd9\u5f52\u56e0\u4e8e\u8be5\u6846\u67b6\u4e2d\u76f8\u4e92\u4ea4\u4e92\u7684\u591a\u4e2a\u6a21\u5757\u3002\u5bf9\u6b64\uff0c\u591a\u91cd\u635f\u5931\u901a\u8fc7\u6821\u51c6\u5668 C \u548c\u9274\u522b\u5668 D \u751f\u6548\uff0c\u5176\u4e2d\u524d\u8005\u60e9\u7f5a\u4e0d\u540c\u6279\u6b21\u7684\u57df\u4e0d\u5339\u914d\uff0c\u540e\u8005\u5956\u52b1\u4e0d\u540c\u6279\u6b21\u4e2d\u76f8\u540c\u7c7b\u522b\u7684\u76f8\u4f3c\u6027\u3002\u8fd9\u4e24\u4e2a\u4efb\u52a1\u7684\u8054\u5408\u5b66\u4e60\u53ef\u4ee5\u5927\u5927\u63d0\u9ad8\u7f51\u7edc\u7684\u6574\u4f53\u6027\u80fd\u3002<\/p>\n<p>\u5df2\u7ecf\u5f00\u53d1\u4e86\u76f8\u5f53\u591a\u7684\u8ba1\u7b97\u65b9\u6cd5\u6765\u6d88\u9664\u6279\u6b21\u6548\u5e94\uff0c\u7279\u522b\u662f\u5728\u57fa\u56e0\u7ec4\u5b66\u548c\u8f6c\u5f55\u7ec4\u5b66\u9886\u57df\u3002\u7136\u800c\uff0c\u5b83\u4eec\u5728\u63d0\u9ad8\u57fa\u4e8e MALDI MS \u7684\u4ee3\u8c22\u7ec4\u5b66\u7684\u8bca\u65ad\u51c6\u786e\u6027\u65b9\u9762\u53ef\u80fd\u4e0d\u592a\u6709\u6548\u3002\u4ee5 ComBat \u4e3a\u4f8b\uff0c\u5728\u5b9e\u9a8c\u4e2d\uff0c\u51c6\u786e\u7387\u57fa\u672c\u4fdd\u6301\u5728\u539f\u59cb\u6570\u636e\u7684\u6c34\u5e73\u3002fSVA \u7684\u7b97\u6cd5\u6700\u521d\u662f\u9488\u5bf9\u9884\u6d4b\u6216\u5206\u7c7b\u4efb\u52a1\u800c\u8bbe\u8ba1\u7684\uff0c\u56e0\u6b64\u5b83\u53ef\u4ee5\u4ea7\u751f\u6bd4 ComBat \u6216 ratio_G \u66f4\u597d\u7684\u6027\u80fd\u3002<\/p>\n<p>\u867d\u7136 ResNet \u662f\u57fa\u4e8e\u6df1\u5ea6\u5b66\u4e60\u7684\uff0c\u4f46\u5728\u51c6\u786e\u7387\u4e0a\u5e76\u4e0d\u4f18\u4e8e fSVA\uff0c\u5982\u8868 5 \u6240\u793a\u3002\u4e00\u4e2a\u53ef\u80fd\u7684\u539f\u56e0\u662f\u5b83\u6ca1\u6709\u5145\u5206\u5229\u7528\u6e90\u6807\u7b7e\u63d0\u4f9b\u7684\u76d1\u7763\u3002\u81f3\u4e8e 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CyTOF \u6570\u636e\u6a21\u62df\u7814\u7a76\u7684\u5206\u7c7b\u7ed3\u679c\uff0c\u4eba\u4eec\u53ef\u80fd\u4f1a\u6ce8\u610f\u5230\u60a3\u8005 1 \u7684\u6279\u6b21\u5185\u5341\u500d\u4ea4\u53c9\u9a8c\u8bc1\u4ea7\u751f\u7684 AUC \u4e3a 0.961\u3002\u867d\u7136\u5728\u6279\u5185\u9a8c\u8bc1\u4e2d\u5b8c\u5168\u6392\u9664\u4e86\u6279\u6548\u5e94\uff0c\u4f46\u5e94\u5c06\u8fd9\u56db\u4e2a\u6307\u6807\u89c6\u4e3a\u8de8\u6279\u9a8c\u8bc1\u7684\u6027\u80fd\u4e0a\u9650\u3002\u7136\u800c\uff0c\u5f53\u5c06\u7b2c 2 \u5929\u4f5c\u4e3a\u6e90\u5e76\u5c06\u7b2c 1 \u5929\u4f5c\u4e3a\u76ee\u6807\u65f6\uff0c\u8de8\u6279\u6b21 AUC \u4e3a 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